血小板
组织因子
血小板活化
血栓调节蛋白
细胞生物学
分子生物学
受体
炎症
脂多糖
白细胞介素
血小板因子4
作者
Franz-Josef Neumann,Nikolaus Marx,Meinrad Gawaz,Korbinian Brand,Ilka Ott,Claudia Rokitta,Christian Sticherling,Christian Meinl,Andreas E. May,Albert Schömig
出处
期刊:Circulation
[Ovid Technologies (Wolters Kluwer)]
日期:1997-05-20
卷期号:95 (10): 2387-2394
被引量:344
标识
DOI:10.1161/01.cir.95.10.2387
摘要
Background Activated platelets tether and activate myeloid leukocytes. To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI. Methods and Results We obtained peripheral venous blood samples in 20 patients with AMI before and daily for 5 days after direct percutaneous transluminal coronary angioplasty (PTCA) and in 20 patients undergoing elective PTCA. Throughout the study period, CD41 immunofluorescence of leukocytes (flow cytometry) revealed increased leukocyte-platelet adhesion in patients with AMI compared with control patients (mean±SE of fluorescence [channels] before PTCA: 77±16 versus 35±9; Pequals;.003). In vitro, thrombin-stimulated fixed platelets bound to neutrophils and monocytes. Within 2 hours, this resulted in increased mRNA for interleukin (IL)-1β, IL-8, and monocyte chemoattractant protein (MCP)-1 in unfractionated ...
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