心肌梗塞
生物
血管生成
干细胞
牙髓干细胞
心功能曲线
结扎
心脏病学
离体
内科学
梗塞
体内
癌症研究
细胞生物学
医学
心力衰竭
分子生物学
生物技术
作者
Carolina Gandía,Ana Armiñán,José Manuel Garcı́a-Verdugo,Elisa Lledó,Amparo Ruı́z,Marı́a-Dolores Miñana,Jorge Sánchez-Torrijos,Rafael Payá,Vicente Mirabet,Francisco Carbonell-Uberos,Mauro Llop,José Montero,Pilar Sepúlveda
出处
期刊:Stem Cells
[Oxford University Press]
日期:2007-12-13
卷期号:26 (3): 638-645
被引量:341
标识
DOI:10.1634/stemcells.2007-0484
摘要
Abstract Human dental pulp contains precursor cells termed dental pulp stem cells (DPSC) that show self-renewal and multilineage differentiation and also secrete multiple proangiogenic and antiapoptotic factors. To examine whether these cells could have therapeutic potential in the repair of myocardial infarction (MI), DPSC were infected with a retrovirus encoding the green fluorescent protein (GFP) and expanded ex vivo. Seven days after induction of myocardial infarction by coronary artery ligation, 1.5 × 106 GFP-DPSC were injected intramyocardially in nude rats. At 4 weeks, cell-treated animals showed an improvement in cardiac function, observed by percentage changes in anterior wall thickening left ventricular fractional area change, in parallel with a reduction in infarct size. No histologic evidence was seen of GFP+ endothelial cells, smooth muscle cells, or cardiac muscle cells within the infarct. However, angiogenesis was increased relative to control-treated animals. Taken together, these data suggest that DPSC could provide a novel alternative cell population for cardiac repair, at least in the setting of acute MI. Disclosure of potential conflicts of interest is found at the end of this article.
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