化学
链式转移
分子印迹聚合物
聚合
硅胶
木筏
甲基丙烯酸
分子印迹
吸附
高分子化学
吸附剂
聚合物
化学工程
色谱法
自由基聚合
有机化学
选择性
催化作用
工程类
作者
Yong Li,Wen-Hui Zhou,Huang‐Hao Yang,Xiaoru Wang
出处
期刊:Talanta
[Elsevier]
日期:2009-07-15
卷期号:79 (2): 141-145
被引量:46
标识
DOI:10.1016/j.talanta.2009.03.014
摘要
Molecularly imprinted polymers (MIPs) were grafted successfully from the surface of silica gel particles via surface initiated reversible addition-fragmentation chain transfer (RAFT) polymerization using RAFT agent functionalized silica gel as the chain transfer agent. The intrinsic characteristics of the controlled/living polymerization mechanism of RAFT allowed for the effective control of the grafting process. Thus the grafting copolymerization of methacrylic acid and divinyl benzene in the presence of template theophylline led to thin MIP film coating silica gel (MIP-Silica). The thickness of MIP film prepared in this study is about 1.98 nm, which was calculated from the nitrogen sorption analysis results. Measured binding kinetics for theophylline to the MIP-Silica and MIPs prepared by conventional bulk polymerization demonstrated that MIP-Silica had improved mass-transfer properties. In addition, the theophylline-imprinted MIP-Silica was used as the sorbent in solid-phase extraction to determine theophylline in blood serum with satisfactory recovery higher than 90%. Nonspecific adsorption of interfering compounds can be eliminated by a simple elution with acetonitrile, without sacrificing the selective binding of theophylline.
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