胰岛素抵抗
2型糖尿病
糖尿病
蛋白质酪氨酸磷酸酶
肥胖
医学
瘦素
内科学
胰岛素
疾病
内分泌学
调节器
2型糖尿病
磷酸酶
药理学
癌症研究
酪氨酸激酶
生物信息学
生物
磷酸化
生物化学
受体
基因
作者
Theodore M. Johnson,Jacques Ermolieff,Michael R. Jirousek
摘要
Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need for new agents to treat these disease states. Resistance to the hormones insulin and leptin are hallmarks of both type 2 diabetes and obesity. Drugs that can ameliorate this resistance should be effective in treating type 2 diabetes and possibly obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to function as a negative regulator of insulin and leptin signal transduction. This article reviews PTP1B as a novel target for type 2 diabetes, and looks at the challenges in developing small-molecule inhibitors of this phosphatase.
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