Diabetes and Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms—What do We Know?

No AccessJournal of Urology1 Dec 2009Diabetes and Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms—What do We Know? Aruna V. Sarma, J. Kellogg Parsons, Kevin McVary, and John T. Wei Aruna V. SarmaAruna V. Sarma Department of Epidemiology, University of Michigan, Ann Arbor, Michigan More articles by this author , J. Kellogg ParsonsJ. Kellogg Parsons Department of Urology, University of California-San Diego, San Diego, California Financial interest and/or other relationship with American Medical Systems. More articles by this author , Kevin McVaryKevin McVary Department of Urology, Northwestern University, Chicago, Illinois Financial interest and/or other relationship with GlaxoSmithKline, Pfizer, Lilly/ICOS, Sanovi Aventis, Allergan and National Institutes of Diabetes and Digestive and Kidney Diseases. More articles by this author , and John T. WeiJohn T. Wei University of Michigan, Department of Urology, Ann Arbor, Michigan Financial interest and/or other relationship with Sanofi, American Medical Systems, Envisioneering, Gen-Probe and Beckman. More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.07.088AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Benign prostatic hyperplasia and associated lower urinary tract symptoms are highly prevalent in older men and represent a substantial challenge to public health. Apart from the prevalence of benign prostatic hyperplasia increasing with age, little is understood regarding its etiology and natural history. Increasing evidence recently pointed toward relationships between diabetes and benign prostatic hyperplasia/lower urinary tract symptoms. We present an overview of the current understanding of clinical and epidemiological research on diabetes and benign prostatic hyperplasia/lower urinary tract symptoms, the hypothesized pathophysiological mechanisms linking the conditions and recommendations for future directions for research. Materials and Methods: A structured, comprehensive literature review was done to identify studies of the relationships between benign prostatic hyperplasia and lower urinary tract symptoms, and diabetes in older men. Results: A substantial proportion of the existing body of literature supports an association between diabetes and benign prostatic hyperplasia/lower urinary tract symptoms. However, failure to differentiate lower urinary tract symptoms from benign prostatic hyperplasia contributed to some of the confusing evidence in studies including more specific benign prostatic hyperplasia measurements. This could be due in part to the largely cross-sectional analyses, the use of select or different study populations, limited sample sizes and inadequate control of potential confounders. Conclusions: Diabetes may substantially influence the risk of benign prostatic hyperplasia and lower urinary tract symptoms in older men. Further prospective, longitudinal analyses of the impact of diabetes and its etiological mechanisms on benign prostatic hyperplasia/lower urinary tract symptoms may identify novel interventions to prevent, diagnose and treat these highly prevalent conditions. References 1 : Urologic Diseases in America Project: benign prostatic hyperplasia. J Urol2005; 173: 1256. Link, Google Scholar 2 : Diabetes and benign prostatic hyperplasia: emerging clinical connections. Curr Urol Rep2009; 10: 4. Google Scholar 3 : The development of human benign prostatic hyperplasia with age. J Urol1984; 132: 474. 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Volume 182Issue 6SDecember 2009Page: S32-S37 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsurination disordersdiabetes mellitusagingurinary tractprostatic hyperplasiaMetricsAuthor Information Aruna V. Sarma Department of Epidemiology, University of Michigan, Ann Arbor, Michigan More articles by this author J. Kellogg Parsons Department of Urology, University of California-San Diego, San Diego, California Financial interest and/or other relationship with American Medical Systems. More articles by this author Kevin McVary Department of Urology, Northwestern University, Chicago, Illinois Financial interest and/or other relationship with GlaxoSmithKline, Pfizer, Lilly/ICOS, Sanovi Aventis, Allergan and National Institutes of Diabetes and Digestive and Kidney Diseases. More articles by this author John T. Wei University of Michigan, Department of Urology, Ann Arbor, Michigan Financial interest and/or other relationship with Sanofi, American Medical Systems, Envisioneering, Gen-Probe and Beckman. More articles by this author Expand All Advertisement PDF downloadLoading ...