Direct Organocatalytic and Highly Enantio‐ and Diastereoselective Mannich Reactions of α‐Substituted α‐Cyanoacetates

Metal-free catalysis: Highly functionalized molecules with two contiguous stereocenters are easily accessed in high yield with high enantio- and diastereoselectivity by using a commercially available organocatalyst ((DHQD)2PYR, see scheme). The easily removed Boc protecting group in the product is an added value to this method as an important tool in asymmetric synthesis. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500144_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.