Incidence and clinicopathological characteristics of intraductal carcinoma detected in prostate biopsies: a prospective cohort study

Aims Intraductal carcinoma of the prostate ( IDC ‐ P ) is a distinct clinicopathological entity and is associated with aggressive, high‐grade and high‐volume prostate carcinoma ( PC a). The incidence, clinicopathological characteristics and prognostic significance of IDC ‐ P have not been reported in prostate biopsies ( PB x) that surgical pathologists encounter in their daily practice. Methods and results In 1176 prospectively collected PB x, 33 IDC ‐ P cases were identified (2.8%). The mean age of patients with IDC ‐ P was 65 (range 46–79) years and mean serum prostate‐specific antigen was 16.2 (range 0.4–105.6) ng/ml. Three (0.26%) IDC ‐ P cases did not have a concomitant invasive PC a. Of 30 cases with concomitant invasive PC a, G leason score was 7 in 16 (53.3%), 8 in four (13.3%) and 9 in 10 (33.3%) cases. The mean number of biopsy cores involved by PC a was 7.2 (range 1–14). Nine patients were treated with radical prostatectomy. Seminal vesicle invasion was found in four of nine (44%) cases, significantly higher than the risk of 12% predicted by P artin Tables ( P = 0.016). Conclusions This is the first prospective study that has investigated the incidence and prognostic significance of IDC ‐ P diagnosed in PB x encountered in daily practice. It is critical for surgical pathologists to diagnose and report IDC ‐ P in PB x.