金盏花
传统医学
生药学
官房
民间医学
医学
生物
化学
生物活性
生物化学
体外
作者
Karin Zitterl-Eglseer,Silvio Sosa,J. Jurenitsch,Manfred Schubert‐Zsilavecz,R. Della Loggia,Aurelia Tubaro,Michele Corrêa Bertoldi,Chlodwig Franz
标识
DOI:10.1016/s0378-8741(97)00061-5
摘要
Separation and isolation of the genuine faradiol esters (1, 2) from flower heads of Marigold (Calendula officinalis L., Asteraceae) could be achieved by means of repeated column chromatography (CC) and HPLC for the first time. Structure elucidation of faradiol-3-myristic acid ester 1, faradiol-3-palmitic acid ester 2 and ψ-taraxasterol 3 has been also performed, without any previous degradation by means of MS, 1H-NMR, 13C-NMR and 2D-NMR experiments. The anti-oedematous activities of these three compounds were tested by means of inhibition of Croton oil-induced oedema of the mouse ear. Both faradiol esters showed nearly the same dose dependent anti-oedematous activity and no significant synergism appeared with their mixture. The free monol, ψ-taraxasterol, had a slightly lower effect. Furthermore, faradiol was more active than its esters and than ψ-taraxasterol and showed the same effect as an equimolar dose of indomethacin.
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