医学
细胞毒性T细胞
免疫学
人类白细胞抗原
移植
淋巴增殖性病變
爱泼斯坦-巴尔病毒
病毒
疾病
移植物抗宿主病
内科学
胃肠病学
抗原
淋巴瘤
生物
体外
生物化学
作者
Tanzina Haque,Gwen Wilkie,Clare Taylor,Peter Amlot,Parvez Murad,Angela Iley,Dilani Dombagoda,Kate M Britton,Anthony Swerdlow,Dorothy H. Crawford
出处
期刊:The Lancet
[Elsevier]
日期:2002-08-01
卷期号:360 (9331): 436-442
被引量:338
标识
DOI:10.1016/s0140-6736(02)09672-1
摘要
Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disease (PTLD) is a common, often fatal, complication of bone-marrow and solid-organ transplantation. Since tumour growth results from inadequate T-cell control of latent EBV, new immunotherapeutic approaches to treatment are being pioneered.In a phase 1/2 trial, eight patients with progressive PTLD unresponsive to conventional treatment were given one to six infusions of partly HLA-matched allogeneic EBV-specific cytotoxic T lymphocytes (CTLs) from a frozen bank of CTLs derived from healthy blood donors.Of the five patients who completed treatment, three had complete remission and two had no clinical response. One patient partly responded after two infusions. No graft-versus-host disease or allo-specific antibodies were detected, and graft function improved in three cases. Tumour responses were mainly seen in those with early, localised, polyclonal disease. EBV load in peripheral blood fell to undetectable levels in all patients who responded to treatment, but was more variable in those who did not.Treatment of EBV-associated PTLD with partly HLA-matched CTLs grown from unrelated donors is effective. Spontaneous remission is very unlikely to account for tumour regression in our patients; however, a larger, controlled trial is needed to assess this treatment further. The frozen bank of allogeneic CTLs is less prohibitively labour intensive and expensive for wide scale use than treatment with autologous CTLs. Such banks could be established to treat other infectious and neoplastic diseases in many patients.
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