Intelligent Wearable Fluorescence Hydrogel-Imprinted Sensor for Rapid Noninvasive Simultaneous Detection of Capecitabine and 5-Fluorouracil in Sweat

patch can effectively collect sweat from the hydrogel to facilitate quantitative detection. Under smartphone detection mode, the COF/CdTe@MIP hydrogel sensor can visually recognize and simultaneously detect CAP and 5-FU within the linear concentration ranges of 0.02-3.6 and 0.01-1.6 μM, respectively. With the assistance of automated smartphone-based image processing, the wearable fluorescence hydrogel-imprinted sensor achieves rapid identification of CAP and 5-FU within 7 min. This wearable fluorescence hydrogel-imprinted sensor provides a feasible method for rapid visual real-time monitoring of anticancer drugs and their metabolites in sweat.