Eco-Friendly Synthesis of Aminophenoxazinones from Aminophenols Catalyzed by Polyoxovanadate-Based MOFs Using Molecular Oxygen

not only exhibits satisfactory substrate tolerance but can also be recovered and reused for at least five cycles without compromising performance. More importantly, the catalyst also performed excellently in a gram-scale reaction (100 mmol, 10.9 g), delivering a 98.0% yield (49.0 mmol, 10.4 g) with a turnover number (TON) of 4900 and a low E-factor of 0.83, thus demonstrating the process to be both efficient and environmentally friendly. A polyoxovanadate-cobalt framework with dual-active sites catalyzes the additive-free oxidative condensation of o-aminophenols to aminophenoxazinones using molecular oxygen as an oxidant in a green ethanol medium, demonstrating excellent performance, recyclability, and feasibility for gram-scale reactions.