Novel Lewis Acid-Assisted Chiral Lewis Acid (LLA) System: Development of Boroxin-Ti-BINOL-Catalyzed Asymmetric Allylation of Aldehydes

The formation of hetero multimetallic complex having B-O-Ti bond could increase the Lewis acidity of titanium. A novel LLA system made up of Ti-BINOL and 4-(trifluoromethyl)phenylboroxin dramatically accelerated the allylation reaction of aldehyde with high enantioselectivity.