化学
对映选择合成
试剂
烷基
催化作用
三氟甲基
铜
格氏试剂
组合化学
有机化学
作者
Minyan Wang,Xinghui Pu,Yunfei Zhao,Panpan Wang,Zexian Li,Chendan Zhu,Zhuangzhi Shi
摘要
A copper-catalyzed system has been introduced for the enantioselective defluoroalkylation of linear 1-(trifluoromethyl)alkenes through C–F activation to synthesize various gem-difluoroalkenes as carbonyl mimics. For the first time, arylboronate-activated alkyl Grignard reagents were uncovered in this cross-coupling reaction. Mechanistic studies confirmed that the tetraorganoborate complexes generated in situ were the key reactive species for this transformation.
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