Metal‐Free [3,3]‐Sigmatropic Rearrangement/[3+2] Annulation Cascade of N‐Phenoxy Amides with Terminal Alkynes for the Diastereoselective Synthesis of trans‐Dihydrobenzofurans

Abstract An efficient synthetic route for the diastereoselective construction of trans ‐dihydrobenzofurans via cascade [3,3]‐sigmatropic rearrangement/[3+2] annulation sequences has been developed. This protocol represents a metal‐free transformation of the promising N ‐phenoxy amides with terminal alkynes and features mild conditions, good functional group compatibility, and practical synthetic potential. magnified image