精子发生
支持细胞
生物
体细胞
细胞生物学
间质细胞
间质细胞
男性不育
内分泌学
内科学
不育
激素
促黄体激素
癌症研究
医学
基因
遗传学
怀孕
作者
Rui Zhou,Jingrouzi Wu,Bang Liu,Yiqun Jiang,Wei Chen,Jian Li,Quanyuan He,Zuping He
标识
DOI:10.1007/s00018-019-03101-9
摘要
Spermatogenesis is fundamental to the establishment and maintenance of male reproduction, whereas its abnormality results in male infertility. Somatic cells, including Leydig cells, myoid cells, and Sertoli cells, constitute the microenvironment or the niche of testis, which is essential for regulating normal spermatogenesis. Leydig cells are an important component of the testicular stroma, while peritubular myoid cells are one of the major cell types of seminiferous tubules. Here we addressed the roles and mechanisms of Leydig cells and myoid cells in the regulation of spermatogenesis. Specifically, we summarized the biological features of Leydig cells and peritubular myoid cells, and we introduced the process of testosterone production and its major regulation. We also discussed other hormones, cytokines, growth factors, transcription factors and receptors associated with Leydig cells and myoid cells in mediating spermatogenesis. Furthermore, we highlighted the issues that are worthy of further studies in the regulation of spermatogenesis by Leydig cells and peritubular myoid cells. This review would provide novel insights into molecular mechanisms of the somatic cells in controlling spermatogenesis, and it could offer new targets for developing therapeutic approaches of male infertility.
科研通智能强力驱动
Strongly Powered by AbleSci AI