Letter in response to glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning

We read with interest the study by Basalay et al 1 recently published in Cardiovascular Research investigating the mechanism of remote ischaemic conditioning (RIc) signalling. Whilst the results are intriguing, a number of unresolved issues remain when considering RIc in humans. First, the authors state that Glucagon-like Peptide 1 (GLP-1) had a protective effect against ischaemia-reperfusion injury in humans. It is noteworthy that the cardioprotective effect of GLP-1 in humans is …