对映选择合成
荧光
氨基酸
手性(物理)
对映体
赫拉
化学
立体化学
生物化学
催化作用
手征对称性
体外
光学
物理
量子力学
Nambu–Jona Lasinio模型
夸克
作者
Chaoyuan Zeng,Xiaoling Zhang,Lin Pu
标识
DOI:10.1002/chem.201605028
摘要
Abstract 1,1′‐Spirobiindane‐7,7′‐diol (SPINOL)‐based chiral aldehydes ( R )‐ and ( S )‐ 3 , in combination with Zn 2+ , are highly enantioselective fluorescent sensors for structurally diverse chiral amino acids. Application of this enantiomeric sensor pair in HeLa cells containing a free amino acid shows that the chirality‐matched sensor–amino acid interaction leads to strong blue emission and chirality mismatch gives only weak fluorescence. This allows a quick determination of the chiral configuration of the free amino acid in the cells. It represents the first enantioselective fluorescent imaging of free amino acids in living cells.
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