P1‐054: Feasibility of Multidomain Cognitive Rehabilitation Incorporating Computerized 3‐Dimensional Virtual Technology for Persons With Dementia

The efficacy of cognitive stimulation as a non-pharmacological intervention in dementia is often well received. In time-constrained health care centers with shortage of staff, it would be beneficial to assess the feasibility of using new technology for cognitive rehabilitation. In this study, we evaluate the effectiveness of a multidomain cognitive rehabilitation programme which include a computerized 3-Dimensional virtual environment. Preliminary studies were conducted to assess the feasibility of 3D equipment for persons with and without dementia (N= 8). The equipment was calibrated by 3D technologist so as to make it user friendly. The program was then developed with advice from Subject Matter Experts (SME) to motivate and stimulate participants. The NNI-3D Cognitive stimulation program is multi component, consisting of psychological well-being through deep-breathing exercises, provision of theoretical knowledge on memory strategies and navigation in the 3D environment in one of 2 scenarios, namely a virtual supermarket and a virtual kitchen. Participants engaged in the activities facilitated by psychologists. Tasks tapped on various cognitive abilities including attention, decision-making, memory, visuospatial orientation and psychomotor ability. Cognitive assessment, emotional state and quality of life assessment were compared at both end points of before and after intervention. A total of 23 participants took part in this pilot phase. 39.1% were patients with Mild Alzheimer’s disease and the remaining were subjects with Mild Cognitive Impairment. Mean age 66.43 years, mean education 13.17 years. 43.5% were Males and 87% were Chinese. There was attrition rate of 26%. Post intervention, the non-dementia group had higher levels of daily functioning (IADL, 6.98 vs 7.71), cognition (MoCA, 28.18 vs 28.78) & visual storage(WMS-VR Delayed 34.24 vs 37.56). In addition, those with mild dementia had better quality of life (DEM-QOL, 1.22 vs 1.13) and reported lower levels of depression (DASS21-D, 3.58 vs 3.43), anxiety (DASS21-A. 4.15 vs 3.31) and stress (DASS-S, 3.33 vs 2.73) post intervention. A multidomain cognitive rehabilitation programme incorporating computerized 3-dimensional virtual technology is feasible and may be a useful strategy in patients with mild dementia and mild cognitive impairment. The study is underway and more data is being collected. Performance of Healthy Controls Performance of mild dementia subjects