Studies on the organ hydrolysate

The hydrolysate of the mucous membrane of hog stomach treated by the diluted sulphuric acid has the most remarkable effect on the experimental ulcer of the rabbit and the toad in comparison with the hydrolysate of the muscular part of the stomach or intestine. The healing of the ulcer has been accelerated by the continuous administration of the hydrolysate consequently such treated toads survived longer than the control animals. The hydrolysate restrained the gastric juice secretion. Likewise the total acidity and content of free hydrochloric acid in the juice decreased. Furthermore, the hydrolysate showed the haematopoietic action. The increase of erythrocytes and reticulocytes was observed in the rabbits which were given the hydrolysate injections. The chemical structure of the active principle in the hydrolyse is still unknown but through the paperpartition chromatography the active principle seems to be a peptide like substance which is attendant on some amino acid.