Current Advances in Pulsatile Drug Delivery System

The advances in reasearches on several pulsatile drug delivery systems in recent years are reviewed.Pulsatile drug delivery systems are the new type of drug delivery.Its design is based on chronopharmacology and biological rhythms,and is aimed at time-controlled and quantity-controlled delivery.The systems are classified into three categories by the delivery mechanisms and design rationales,namely,pre-programmed drug delivery system,close-loop delivery system and open-loop delivery system.