高甘油三酯血症
乳糜微粒
极低密度脂蛋白
内科学
脂蛋白脂酶
甘油三酯
内分泌学
甘油三酯脂肪酶
肾脏疾病
医学
脂蛋白
中密度脂蛋白
肝脂肪酶
胆固醇
化学
脂肪组织
出处
期刊:PubMed
日期:2013-09-01
卷期号:71 (9): 1618-22
被引量:2
摘要
In advanced chronic kidney disease(CKD), chylomicrons(CM) and very low density lipoprotein(VLDL) are accumulated by the inactivity of lipoprotein lipase(LPL). CM remnants are incompletely absorbed into liver and the conversion of intermediate lipoprotein (IDL) to cholesterol-rich low density lipoprotein(LDL) is impaired by the lack of hepatic triglyceride lipase(HTGL). As a result, the increase of triglyceride-rich lipoproteins, i.e., CM, CM remnants, VLDL and IDL, shows hypertriglyceridemia. The ratio of triglyceride to cholesterol is also increased in both LDL and HDL. Excess triglyceride-rich lipoproteins are oxidized by oxidative stress in CKD and involved in cardio-vascular diseases. Accordingly, the prevention of hypertriglyceridemia is one of the most important steps for the treatment of CKD.
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