New Applicntion in Lactococcus Lactis as Vaccine Delivery Systems

Lactic acid bacteria are normal in human and animal intestinal which are generally recognized as safe microorganism.Lactococcus lactis is the mode bacteria of lactic acid bacteria and its genome has been sequenced,and using the molecular biology tools,it's easy for the modification of recipient bacteria which are suitable for all kinds of expression vector.Currently it has been developed that a series of plasmid cloning vector,integrated cloning vector system and protein localization system,meanwhile a variety of pathogenic microbial antigens have successfully expressed in Lactococcus lactis.The application situation of Lactococcus lactis in vaccines presenting carrier in recent years have been described,and elaborating research progress in the anti-infective,anti-cancer,anti-autoimmune aspects and difficulties encountered in vaccine development and the prospect are well explained.