1643 TESTOSTERONE CHANGES AFTER RADICAL PROSTATECTOMY FOR PROSTATE CANCER ARE CORRELATED TO POSTOPERATIVE URINARY INCONTINENCE AND CONTINENCE RECOVERY

You have accessJournal of UrologyProstate Cancer: Localized VIII1 Apr 20121643 TESTOSTERONE CHANGES AFTER RADICAL PROSTATECTOMY FOR PROSTATE CANCER ARE CORRELATED TO POSTOPERATIVE URINARY INCONTINENCE AND CONTINENCE RECOVERY Mauro Gacci, Saverio Giancane, Saba Khorrami, Saba Khorrami, Arcangelo Sebastianelli, Claudia Giannessi, Matteo Salvi, Nicola Tosi, Giovanni Corona, Sergio Serni, Mario Maggi, and Marco Carini Mauro GacciMauro Gacci Florence, Italy More articles by this author , Saverio GiancaneSaverio Giancane Florence, Italy More articles by this author , Saba KhorramiSaba Khorrami Florence, Italy More articles by this author , Saba KhorramiSaba Khorrami Florence, Italy More articles by this author , Arcangelo SebastianelliArcangelo Sebastianelli Florence, Italy More articles by this author , Claudia GiannessiClaudia Giannessi Florence, Italy More articles by this author , Matteo SalviMatteo Salvi Florence, Italy More articles by this author , Nicola TosiNicola Tosi Florence, Italy More articles by this author , Giovanni CoronaGiovanni Corona Bologna, Italy More articles by this author , Sergio SerniSergio Serni Florence, Italy More articles by this author , Mario MaggiMario Maggi Florence, Italy More articles by this author , and Marco CariniMarco Carini Florence, Italy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1460AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Radical prostatectomy (RP) for prostate cancer (PCa) can be related with a significant reduction in serum testosterone (T) levels at 1 month postoperatively, with a following improvement at 3-6 months. At the same time, urinary continence can be worsened 1 months after RP, an progressively recovered at 3-6 months. Aim of our study is to assess the correlation between T modifications and urinary continence failure at 1 month and recovery at 3 to 6 months after RP. METHODS We screened 100 men treated with RP for clinically localized PCa. Eighty-two men with preoperative T >10 nMol/L were included in the study. Urinary function (UF) and urinary bother (UB) from the UCLA-PCI questionnaires and serum T levels were assessed preoperatively and 1, 3 and 6 months postoperatively. The correlation between T decrease (T0-1: preop. vs 1 month) and UF and UB decline (UF 0-1, UB 0-1) and the correlations between T increase (T 0-3: preop. vs 3 months; T 0-6: preop. vs 6 months) and UF and UB recovery (UF 0-3, UB 0-3, UF 0-6, UB 0-6) were assessed by using a Spearman correlation coefficient. RESULTS As reported in the figure and the table below, T modifications were strongly correlated with both UF and UB modifications after RP. CONCLUSIONS Our study demonstrated that the significant reduction of T 1 months after RP for PCa, followed by a progressive improvement at 3 to 6 months can influence postoperative urinary function. These outcomes underline the importance of assessing T levels before and after RP. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e664 Peer Review Report Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mauro Gacci Florence, Italy More articles by this author Saverio Giancane Florence, Italy More articles by this author Saba Khorrami Florence, Italy More articles by this author Saba Khorrami Florence, Italy More articles by this author Arcangelo Sebastianelli Florence, Italy More articles by this author Claudia Giannessi Florence, Italy More articles by this author Matteo Salvi Florence, Italy More articles by this author Nicola Tosi Florence, Italy More articles by this author Giovanni Corona Bologna, Italy More articles by this author Sergio Serni Florence, Italy More articles by this author Mario Maggi Florence, Italy More articles by this author Marco Carini Florence, Italy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...