催化作用
钯
化学
硼
配体(生物化学)
联轴节(管道)
碳纤维
偶联反应
金属
药物化学
高分子化学
立体化学
材料科学
有机化学
冶金
复合材料
受体
复合数
生物化学
作者
Liang Zhang,Gabriel J. Lovinger,Emma K. Edelstein,Adam Szymaniak,Matteo Chierchia,James P. Morken
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-01-01
卷期号:351 (6268): 70-74
被引量:263
标识
DOI:10.1126/science.aad6080
摘要
A two-for-one twist on Suzuki coupling The Suzuki-Miyaura coupling reaction is one of the most widely used ways of making carbon-carbon bonds. Essentially a palladium catalyst activates one carbon fragment and then links it to a second fragment pulled from boron. Zhang et al. now demonstrate a twist on the conventional pathway (see the Perspective by Fyfe and Watson). In their system, the palladium initially coaxes together two carbon fragments on one boron center. Then the catalyst stitches a second C-C bond to a third, external fragment. A chiral ligand renders the reaction highly enantio-selective. Science , this issue p. 70 ; see also p. 26
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