The Inter-Species Extrapolation of Propofol PBPK Model

OBJECTIVE To perform the extrapolation of a simplified propofol PBPK model among sheep,rabbit and man.METHODS A simple extrapolation method was proposed.The parameters of the model were extrapolated from sheep to rabbit and human with this method,and the simulated concentrations were compared with the measured. RESULTS The simulated concentrations tallied with those measured.CONCLUSION The method for extrapolation was rational.