THERMAL RADIOFREQUENCY INDUCED PORCINE URETERAL STRICTURE: A CONVENIENT ENDOUROLOGIC MODEL

No AccessJournal of UrologyInvestigative Urology1 Jan 1999THERMAL RADIOFREQUENCY INDUCED PORCINE URETERAL STRICTURE: A CONVENIENT ENDOUROLOGIC MODEL MAURICE ANIDJAR, PIERRE MONGIAT-ARTUS, JEAN PHILIPPE BROULAND, PAUL MERIA, PIERRE TEILLAC, ALAIN LE DUC, PHILIPPE BERTHON, and OLIVIER CUSSENOT MAURICE ANIDJARMAURICE ANIDJAR , PIERRE MONGIAT-ARTUSPIERRE MONGIAT-ARTUS , JEAN PHILIPPE BROULANDJEAN PHILIPPE BROULAND , PAUL MERIAPAUL MERIA , PIERRE TEILLACPIERRE TEILLAC , ALAIN LE DUCALAIN LE DUC , PHILIPPE BERTHONPHILIPPE BERTHON , and OLIVIER CUSSENOTOLIVIER CUSSENOT View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62135-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To establish a reliable model of iatrogenic ureteral stricture mimicking the human clinical situation in order to experiment with new site-specific endourologic treatment concepts. Materials and Methods: After cystoscopic insertion of a 7F right ureteral catheter, we induced external thermal radiofrequency injury to the right upper third ureter at low power setting (10 W) using an open surgical approach in 13 pigs. Three pigs considered as controls underwent the same procedure without application of electrocautery. All 16 animals were initially assessed at 8 days; 3 study animals and the 3 controls were followed for 6 weeks. Results: No control animals had strictures. Significant upper third ureteral strictures with marked hydronephrosis where achieved in all study animals after a mean interval of 9 days, as evidenced by ultrasound examination and retrograde ureteropyelography. Endoscopic retrograde access to these strictures was always possible (mean length 1.4 cm.). Histologic examination displayed severe disorganization of the muscular layer by dense fibrosis composed of collagen bundles with few scattered fibroblasts. 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Link, Google Scholar Laboratoire de Genetique et de Pathobiologie des Tumeurs Prostatiques, Departement d'Urologie, Hopital Saint Louis and the Laboratoire d'Anatomopathologie, Hopital Lariboisiere, Paris, France© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 161Issue 1January 1999Page: 298-303 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information MAURICE ANIDJAR More articles by this author PIERRE MONGIAT-ARTUS More articles by this author JEAN PHILIPPE BROULAND More articles by this author PAUL MERIA More articles by this author PIERRE TEILLAC More articles by this author ALAIN LE DUC More articles by this author PHILIPPE BERTHON More articles by this author OLIVIER CUSSENOT More articles by this author Expand All Advertisement PDF downloadLoading ...