生物
神经嵴
胚胎干细胞
背根神经节
祖细胞
酪氨酸羟化酶
交感神经节
细胞生物学
胆碱乙酰转移酶
神经科学
人口
胚胎
感觉系统
解剖
干细胞
中枢神经系统
多巴胺
遗传学
人口学
社会学
基因
作者
Nancy Paulsen,Steven G. Matsumoto
出处
期刊:Journal of Neurobiology
[Wiley]
日期:2000-04-01
被引量:3
标识
DOI:10.1002/(sici)1097-4695(200004)43:1<31::aid-neu3>3.0.co;2-s
摘要
We have identified a population of progenitor cells in embryonic dorsal root ganglia (DRG) of the mouse. These cells can be induced into proliferating and differentiating into neurons that display multiple characteristics of the sympathetic lineage by a brief exposure to a defined medium. The sympathetic neuronal characteristics include immunoreactivity for the transcription factors MASH-1 and Phox2a and for the neurotransmitter markers tyrosine hydroxylase, choline acetyltransferase, and NPY. The progenitor cells are detected in DRG from embryonic day 11.5 (E11.5) to E15. An identical time course is observed in primary cultures of neural crest, suggesting that the competency of these cells is intrinsically regulated. We also present evidence that the environment of the sensory ganglion, unlike that of a sympathetic ganglion, prevents these cells from differentiating into neurons.
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