The Acute Toxicity of Praziquantel to Grass Carp and Golden Shiners

Abstract The acute toxicity and highest nonlethal concentration of praziquantel (LC0) were determined in the laboratory for grass carp Ctenopharyngodon idella and golden shiner Notemigonus crysoleucas, two cyprinids known to harbor the Asian tapeworm Bothriocephalus acheilognathi. Praziquantel is an anthelmintic used to treat fish with tapeworms. The 24-h and 96-h LC50 values were 55.1 and 49.7 mg/L for golden shiners (1.3 g) and 63.4 and 60.6 mg/L for grass carp (9.1 g). The 24-h and 96-h LC0 values were 50.0 and 45.0 mg/L for golden shiners and 60.0 and 60.0 mg/L for grass carp.