JAK-STAT信号通路
表皮生长因子
酪氨酸磷酸化
车站3
STAT1
细胞生物学
磷酸化
癌症研究
斯达
STAT6
酪氨酸激酶
生物
信号转导
转录因子
化学
分子生物学
生物化学
基因
受体
作者
Zhong Zhong,Zilong Wen,James Darnell
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-04-01
卷期号:264 (5155): 95-98
被引量:1909
标识
DOI:10.1126/science.8140422
摘要
The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). It is likely that this phosphoprotein forms homodimers as well as heterodimers with the first described member of the STAT family, Stat91 (renamed Stat1 alpha), which is activated by the IFNs and EGF. Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface.
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