免疫系统
并行传输
紧密连接
生物
先天免疫系统
细胞生物学
肠道通透性
肠上皮
肠粘膜
胃肠道
免疫学
免疫
上皮
磁导率
医学
生物化学
遗传学
内科学
膜
作者
Ângela Castoldi,Cristhiane Fávero de Aguiar,Pedro M. Moraes‐Vieira,Niels Olsen Saraiva Câmara
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2015-08-10
卷期号:16 (7): 655-671
被引量:28
标识
DOI:10.2174/1389203716666150630133141
摘要
Homeostasis of the immune system depends on several factors. The gastrointestinal tract plays an important role in maintaining our immune system. With this aim, the intestinal immune system interacts with epithelial barrier molecules, especially tight junction proteins, that are key molecules involved in controlling paracellular permeability to increase the protection barrier against external antigens or possibly to respond to commensal microorganisms. During intestinal inflammatory diseases, the expression of innate immune receptors in intestinal epithelial cells and infiltration of immune cells are related, but it is still unclear how the immune system induces modulation of paracellular permeability. In this review, we provide an overview of the understanding of how the immune system modulates the expression of tight junctions to maintain the mucosal immune system.
科研通智能强力驱动
Strongly Powered by AbleSci AI