Rebeccamycin and Staurosporine Biosynthesis: Insight into the Mechanisms of the Flavin‐Dependent Monooxygenases RebC and StaC

Once or twice? RebC and StaC are flavin-dependent monooxygenases that occupy a key branch point in the biosynthesis of the indolocarbazoles rebeccamycin and staurosporine, respectively. A mere two substitutions in the active site of RebC was found to confer StaC reactivity. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.