Base-promoted anaerobic intramolecular cyclization synthesis of 4,5-disubstituted-1,2,3-thiadiazoles

An alkali-promoted, transition-metal-free and oxidant-free method to construct 4,5-disubstituted-1,2,3-thiadiazoles from N -tosylhydrazone-bearing thiocarbamates by employing a sustainable intramolecular reaction strategy has been developed.