树枝状大分子
细胞内
生物物理学
结合
纳米医学
材料科学
药物输送
膜
耗散颗粒动力学模拟
纳米技术
化学
纳米颗粒
聚合物
生物化学
生物
数学分析
复合材料
数学
作者
Ling Gu,Zhenyu Duan,Marc E. Rothenberg,Xiaoling Li,Qiang Luo,Apanpreet Kaur Bhamra,Dayi Pan,Hongyan Zhu,Xiaohe Tian,Rongjun Chen,Zhongwei Gu,Hu Zhang,Zhiyong Qian,Qiyong Gong,Qiang Luo
标识
DOI:10.1002/adma.202200048
摘要
Efficient penetration and retention of therapeutic agents in tumor tissues can be realized through rational design of drug delivery systems. Herein, a polymer-dendron conjugate, POEGMA-b-p(GFLG-Dendron-Ppa) (GFLG-DP), is presented, which allows a cathepsin-B-triggered stealthy-to-sticky structural transformation. The compositions and ratios are optimized through dissipative particle dynamics simulations. GFLG-DP displays tumor-specific transformation and the consequently released dendron-Ppa is found to effectively accumulate on the tumor cell membrane. The interaction between the dendron-Ppa and the tumor cell membrane results in intracellular and intercellular transport via membrane flow, thus achieving efficient deep penetration and prolonged retention of therapeutic agents in the solid tumor tissues. Meanwhile, the interaction of dendron-Ppa with the endoplasmic reticulum disrupts cell homeostasis, making tumor cells more vulnerable and susceptible to photodynamic therapy. This platform represents a versatile approach to augmenting the tumor therapeutic efficacy of a nanomedicine via manipulation of its interactions with tumor membrane systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI