化学
组分(热力学)
亚甲基
组合化学
工作(物理)
环境友好型
反应条件
有机化学
催化作用
生态学
机械工程
生物
热力学
物理
工程类
作者
Sadashivamurthy Shamanth,Nagarakere C. Sandhya,Yatheesh Narayana,Sunilkumar Makanahalli P,Mahesha Mamatha,Kanchugarakoppal S. Rangappa,Kempegowda Mantelingu
标识
DOI:10.1080/00397911.2022.2072746
摘要
Present work describes the T3P® mediated one pot four component reaction between 2-aminoacetamide, methylene-active carbonyl compounds, S8 and isothiocyantes in synthesizing 1-(3-cyanothiophen-2-yl)-3-phenylureas. The strategy developed here comprises Gewald reaction followed by the T3P intervened unique intra-molecular rearrangement. The novel and eco-friendly route achieved here is operationally facile and offers versatile 1-(3-cyanothiophen-2-yl)-3-phenylureas, which are expected to show good biological activities.
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