可药性
医学
生物标志物
DNA复制
癌症研究
癌症
DNA再复制
DNA损伤
细胞周期
计算生物学
生物信息学
作者
Runze Liu,Ya-Kai Huang
标识
DOI:10.1007/s12094-022-02853-4
摘要
Due to the bottlenecks encountered in traditional treatment for tumor, more effective drug targets need to be developed. Cell division cycle 7 kinase plays an important role in DNA replication, DNA repair and recombination signaling pathways. In this review, we first describe recent studies on the role of CDC7 in DNA replication in normal human tissues, and then we integrate new evidence focusing on the important role of CDC7 in replication stress tolerance of tumor cells and its impact on the prognosis of clinical oncology patients. Finally, we comb through the CDC7 inhibitors identified in recent studies as a reference for further research in clinical practice.
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