心脏病学
内科学
收缩
医学
射血分数
二尖瓣反流
二尖瓣
斑点追踪超声心动图
心脏周期
心力衰竭
舒张期
血压
作者
Sorina Mihăilă,Denisa Muraru,Marcelo Haertel Miglioranza,Eleonora Piasentini,Patrizia Aruta,Umberto Cucchini,Sabino Iliceto,Dragoş Vinereanu,Luigi P. Badano
出处
期刊:European Journal of Echocardiography
[Oxford University Press]
日期:2016-01-12
卷期号:17 (8): 918-929
被引量:22
摘要
To explore the relationship between the mitral annular (MA) remodelling and dysfunction, mitral regurgitation (MR) severity, left ventricular (LV) and atrial (LA) size and function in patients with organic MR (OMR).A total of 52 patients (57 ± 15 years, 31 men) with mild to severe OMR and 52 controls underwent 3D transthoracic echocardiography acquisitions of the mitral valve (MV), LA, and LV. MA geometry and dynamics, LV and LA volumes, LV ejection fraction (LVEF) and emptying fractions (LAEF) were assessed using dedicated software packages. LA and LV myocardial deformations were assessed using 2D speckle-tracking echocardiography. OMR patients presented larger and more spherical MA than controls during the entire systole (P < 0.001). Although the MA non-planarity at early-systole was similar between OMR and controls (157 ± 13° vs. 153 ± 12°, P = NS), the MA became flatter from mid- to end-systole (153 ± 12 vs. 146 ± 10° and 157 ± 12 vs. 147 ± 8°, P < 0.01) in OMR. MA area fractional change was lower in patients with OMR (22 ± 5% vs. 28 ± 5%, P < 0.001), and correlated with the MR orifice and volume (r = -0.52 and r = -0.55). MA fractional area change correlated with LA minimum and maximum volumes (r = 0.77 and r = 0.70), total and active LAEF (r = 0.72 and r = 0.76), and LA negative strain and strain rate (r = 0.52 and r = 0.57), but not with the LVEF or LV global longitudinal strain. In a multivariate regression model using LAEF and LVEF, solely active LAEF correlated with the MA fractional area change (β = 0.51, P = 0.005).In patients with OMR, MA reduced function correlates with the MR severity and the LA size and function, but not with the LV function.
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