What to Add When Methotrexate Fails in Rheumatoid Arthritis Patients

In methotrexate-treated patients with rheumatoid arthritis (RA), how does the addition of a biologic agent compare with addition of two conventional nonbiologic agents? This question was addressed in a double-blind, placebo-controlled, randomized trial that involved 353 RA patients who had received 15 to 25 mg of methotrexate weekly for at least 12 weeks and who …