生物
果蝇胚胎发生
平动调节
奥斯卡
细胞生物学
卵母细胞
卵子发生
胚胎
胚胎发生
信使核糖核酸
黑腹果蝇
基因表达调控
遗传学
母子转换
胚胎干细胞
RNA结合蛋白
基因
翻译(生物学)
合子
作者
Oona Johnstone,Paul Lasko
出处
期刊:Annual Review of Genetics
[Annual Reviews]
日期:2001-12-01
卷期号:35 (1): 365-406
被引量:306
标识
DOI:10.1146/annurev.genet.35.102401.090756
摘要
Translational control is a prevalent means of gene regulation during Drosophila oogenesis and embryogenesis. Multiple maternal mRNAs are localized within the oocyte, and this localization is often coupled to their translational regulation. Subsequently, translational control allows maternally deposited mRNAs to direct the early stages of embryonic development. In this review we outline some general mechanisms of translational regulation and mRNA localization that have been uncovered in various model systems. Then we focus on the posttranscriptional regulation of four maternal transcripts in Drosophila that are localized during oogenesis and are critical for embryonic patterning: bicoid (bcd), nanos (nos), oskar (osk), and gurken (grk). Cis- and trans-acting factors required for the localization and translational control of these mRNAs are discussed along with potential mechanisms for their regulation.
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