番红花
番红花
红花醛
西红花酸
番红花苷
类胡萝卜素
鸢尾科
植物甾醇
传统医学
植物
细胞生长
癌症研究
乳腺癌
生物
细胞周期
细胞培养
医学
生物化学
癌症
细胞
癌细胞
化学
人体乳房
作者
Dimitra G. Chryssanthi,Fotini N. Lamari,Gregoris Iatroú,Adamantia Pylara,Nikos K. Karamanos,Paul Cordopatis
出处
期刊:Anticancer Research
[International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts]
日期:2007-01-01
卷期号:27: 357-362
被引量:35
摘要
Among the different species of Crocus, only C. sativus has been extensively studied for the composition and the biological properties of its styles, since these constitute the well-known spice saffron, which is widely used in the Mediterranean, Indian and Chinese diet. With high performance liquid chromatography (HPLC) and UV/vis spectroscopy, the presence of hydrophilic carotenoids in the styles of three other Crocus taxa, endemic in Greece, C. boryi ssp. tournefortii, C. boryi ssp. boryi and C. niveus, is reported for the first time. Incubation of MCF-7 and MDA-MB-231 breast cancer cells for 48 h with different concentrations of all four Crocus style extracts showed a dose-dependent inhibitory effect on cell proliferation measured by the MTT assay. The antiproliferative effect was not related to the presence of estrogen receptors. Studies on the effect of trans-crocin-4 (the main carotenoid constituent of C. sativus styles, digentibiosylester of crocetin), crocetin and safranal showed that the antiproliferative effect is attributed to the constituent crocins irrespective of the degree of glycosylation. These results show that the styles of the various Crocus taxa merit further investigation of their composition and mechanisms of action of their carotenoid constituents in order to establish if they could be used as chemopreventive or anticancer agents.
科研通智能强力驱动
Strongly Powered by AbleSci AI