医学
相对风险
前列腺癌
置信区间
荟萃分析
混淆
前列腺
科克伦图书馆
队列研究
内科学
妇科
泌尿科
肿瘤科
癌症
作者
Ke He,Zhangjun Cao,Longfei Peng,Youlu Lu,Xin Wang,Liangkuan Bi
摘要
There have been some conflicting claims whether larger prostate weight (PW) reduces the risk of positive surgical margins (PSMs). This study aims to examine the associations between PW and PSMs. PubMed, Web of Science and Cochrane library were systematically retrieved. Relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were synthesised utilising random-effect models. Ultimately, 22 cohort studies met criteria were enrolled in this meta-analysis, of which 18 studies reporting the RR of the highest VS lowest category of PW yielded the combined RR of PSMs of 0.61 (95% CI 0.50–0.74). Subgroup analysis showed that geographic region and surgical modalities were considered as potential confounders of influence of PW on PSMs. The nonlinear dose–response relationship demonstrated that PSM risk decreased by 1% (RR = 0.99, 95% CI, 0.98–0.99) for every one gram increment in PW. This study suggests PW has a negative association with risk of PSMs, and having a appropriate PW is very important.
科研通智能强力驱动
Strongly Powered by AbleSci AI