The association between prostate weight and positive surgical margins in prostate cancer: A meta‐analysis

AndrologiaVolume 52, Issue 3 e13533 ORIGINAL ARTICLE The association between prostate weight and positive surgical margins in prostate cancer: A meta-analysis Ke He, Ke He Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorZhang-Jun Cao, Zhang-Jun Cao Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorLong-Fei Peng, Long-Fei Peng Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorYou-Lu Lu, You-Lu Lu Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorXin Wang, Xin Wang Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorLiang-Kuan Bi, Corresponding Author Liang-Kuan Bi biliangkuanay@163.com orcid.org/0000-0002-2826-9357 Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China Correspondence Liang-Kuan Bi, Department of Urology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei 230032, Anhui, China. Email: biliangkuanay@163.comSearch for more papers by this author Ke He, Ke He Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorZhang-Jun Cao, Zhang-Jun Cao Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorLong-Fei Peng, Long-Fei Peng Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorYou-Lu Lu, You-Lu Lu Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorXin Wang, Xin Wang Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaSearch for more papers by this authorLiang-Kuan Bi, Corresponding Author Liang-Kuan Bi biliangkuanay@163.com orcid.org/0000-0002-2826-9357 Departmemt of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China Correspondence Liang-Kuan Bi, Department of Urology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei 230032, Anhui, China. Email: biliangkuanay@163.comSearch for more papers by this author First published: 06 February 2020 https://doi.org/10.1111/and.13533 He, Cao and Peng are contributed equally to this paper. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract There have been some conflicting claims whether larger prostate weight (PW) reduces the risk of positive surgical margins (PSMs). This study aims to examine the associations between PW and PSMs. PubMed, Web of Science and Cochrane library were systematically retrieved. Relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were synthesised utilising random-effect models. Ultimately, 22 cohort studies met criteria were enrolled in this meta-analysis, of which 18 studies reporting the RR of the highest VS lowest category of PW yielded the combined RR of PSMs of 0.61 (95% CI 0.50–0.74). Subgroup analysis showed that geographic region and surgical modalities were considered as potential confounders of influence of PW on PSMs. The nonlinear dose–response relationship demonstrated that PSM risk decreased by 1% (RR = 0.99, 95% CI, 0.98–0.99) for every one gram increment in PW. This study suggests PW has a negative association with risk of PSMs, and having a appropriate PW is very important. CONFLICT OF INTEREST The authors declare that they have no conflict of interest. Supporting Information Filename Description and13533-sup-0001-FigS1.jpgJPEG image, 373.5 KB Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume52, Issue3April 2020e13533 RelatedInformation