氧化应激
肾
急性肾损伤
促炎细胞因子
抗氧化剂
医学
药理学
缺血
再灌注损伤
炎症
内科学
化学
生物化学
作者
Ömer Topdağı,Ayhan Tanyeli,Fazile Nur Ekinci Akdemir,Ersen Eraslan,Mustafa Can Güler,Selim Çomaklı
出处
期刊:Life Sciences
[Elsevier]
日期:2020-02-01
卷期号:242: 117217-117217
被引量:27
标识
DOI:10.1016/j.lfs.2019.117217
摘要
Kidney ischemia reperfusion (IR) injury is an important health problem resulting in acute kidney failure. The oxidative stress and inflammatory process are the underlying mechanisms of IR injury. It has been purposed in this study to research the possible protective effects of fraxin on kidney injury induced by IR.32 Sprague Dawley male rats were divided into 4 groups. The groups were organized as follows; sham, IR, IR + fraxin 10 mg/kg, and IR + 50 mg/kg fraxin groups. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues removed at the end of our experimental study.It was detected that the oxidant and proinflammatory markers increased and antioxidant parameters decreased in IR group but the results significantly reversed in treatment groups compared to IR group. And also, 8-OHdG, NF-κB, HAVCR1 immunopositivities were at severe levels and these results attenuated in IR fraxin + 10 mg/kg, and IR + fraxin 50 mg/kg groups.These presented results have shown that fraxin performed protective effects against kidney injury induced by IR.
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