Application progress of recombinant human growth hormone in assisted reproductive technology

In order to improve the outcome of in vitro fertilization-embryo transfer (IVF-ET) treatment, recombinant human growth hormone (rhGH) has been widely used in assisted reproductive technology (ART)， and has obvious improvement in patients with ovarian dysfunc-tion, such as diminished ovarian reserve (DOR), poor ovarian response (POR), polycystic ovary syndrome (PCOS), and abnormal endometrium patients such as repeated implantation failed (RIF), thin endometrium and intrauterine adhesions (IUA). But there is no unified standard about the target patients and application protocol of rhGH. This paper summarizes the mechanism and usage of rhGH in the above patients. Key words: Fertilization in vitro; Embryo transfer; Reproductive techniques, assisted; Recombinant human growth hormone; Ovarian dysfunction; Abnormal endometrium