Analysis of stage and clinical pathological characteristics of invasive lobular carcinoma with the 8th AJCC Cancer Staging system

Objective To study the meaning of breast cancer staging system by AJCC eighth edition to invasive lobular carcinoma and analysis the clinical pathological characteristics. Methods According to the eighth edition of the AJCC staging to evaluate the TNM stage and prognosis evaluation of invasive lobular carcinoma cancer patient in Peking University Shenzhen Hospital from 2011 to 2016, and compared with others in clinical pathological data. Results There were 21 cases of invasive lobular carcinoma, accounting for 2.7% of all invasive breast cancer. We found that invasive lobular carcinoma shows no significant difference (P>0.05) in ages, menstrual status, molecular features and anatomic staging and prognosis staging with others; histological grade were significantly different (P< 0.05). There were significant differences in the prognosis and staging of invasive lobular carcinoma. Conclusions Eighth AJCC staging system provides a new reference for the clinical treatment of breast cancer, should be evaluated with anatomic stage. Histological grade is relatively good in invasive lobular carcinoma and the prognosis is good, needs more research to the individualized treatment of invasive lobular carcinoma. Key words: Breast neoplasms; 8th AJCC cancer Staging system; Invasive lobular carcinoma; Anatomy; Prognosis