光热治疗
纳米材料
纳米技术
材料科学
纳米棒
表面改性
生物相容性材料
纳米壳
癌症治疗
光热效应
癌症研究
阿霉素
癌症
药物输送
胶体金
医学
生物医学工程
纳米医学
纳米载体
化学
纳米颗粒
物理化学
作者
Ming Zhou,Yunfei Zhou,Yong Cheng,Yutao Wu,Jun Yang,Ziquan Lv
标识
DOI:10.1166/jbn.2020.2938
摘要
Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.
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