Comparative study of the phenolic profile, antioxidant properties, and inhibitory effects of Moringa ( <i>Moringa oleifera</i> Lam.) and Almond ( <i>Terminalia catappa</i> Linn.) leaves on acetylcholinesterase and monoamine oxidase activities in the head region of Fruitfly ( <i>Drosophila melanogaster</i> Meigen) in vitro

Moringa and Almond are medicinal plants used traditionally as food and medicine to prevent and/or treat a wide array of metabolic and neurodegenerative diseases, however, Almond leaf is underutilized. Therefore, this study investigated and compared the polyphenol constituents, antioxidant capacities, and neurochemical indices of the aqueous extracts of Moringa and Almond leaves in fruitfly head tissue homogenate in vitro. The polyphenols were evaluated by characterization using HPLC-DAD, antioxidant properties were assessed through extracts ability to inhibit ABTS, DPPH, OH, and NO radicals, reduce Fe3+ and MDA, and chelate Fe2+ . The neurochemical indices were evaluated through AChE and MAO inhibitory activities. Almond leaf had significant (p < .05) higher polyphenols and antioxidant properties. However, Moringa leaf had significant (p < .05) higher AChE inhibition and no significant (p < .05) difference was obtained in MAO inhibitory activities. Thus, Almond leaf might be more effective in managing diseases related with oxidative stress and neurodegeneration. PRACTICAL APPLICATIONS: This present study has shown that Almond leaf might offer better health promotion due to its higher phenolic constituents and antioxidant activities when compared with Moringa leaf, however, both Moringa and Almond leaves could be taken as functional foods to alleviate the symptoms of oxidative stress and neurodegenerative diseases.