Sanghyeon Lee,Byung-Gyu Kim,Sujeong Geum,Jiheon Kim,Hee‐Yoon Lee
出处
期刊:Organic Letters [American Chemical Society] 日期:2021-06-03卷期号:23 (12): 4651-4656被引量:3
标识
DOI:10.1021/acs.orglett.1c01391
摘要
The first total synthesis of (±)-jujuyane, a cyclooctanoid natural product, was accomplished from a (5 + 3) dimerization product of oxidopyrylium ylide that forms the cyclooctanoid core structure along with inherited stereochemical bias. Selective functional group modifications of the highly oxygenated dimeric structure, followed by the tactical functional group manipulation around the eight-membered carbocyclic core, enabled the total synthesis of (±)-jujuyane, which will serve a guide for future applications of oxidopyrylium dimers to the natural product total synthesis.