明胶
生物复合材料
材料科学
细菌纤维素
生物相容性
自愈水凝胶
增塑剂
羧甲基纤维素
丙烯酸酯
壳聚糖
甘油
生物高聚物
化学工程
复合材料
纤维素
聚合物
高分子化学
化学
共聚物
生物化学
复合数
钠
冶金
工程类
作者
Nadda Chiaoprakobkij,Sutasinee Seetabhawang,Neeracha Sanchavanakit,Muenduen Phisalaphong
标识
DOI:10.1080/09205063.2019.1613292
摘要
Hydrogels from bacterial, algal, and animal cells—bacterial cellulose (BC), alginate, and gelatin, respectively—were combined to fabricate a biocomposite film (BCAGG) via an eco-friendly casting technique. In addition, glycerol was added as a plasticizer to improve the elasticity and water absorption capacity of the film. In this study, BC pellicles were simply deconstructed into fibrils suspension and then reconstructed into films with a supplement of alginate, gelatin and glycerol. The physical appearance of fabricated films resembled native BC but possessed improved ductility, enhanced flexibility, higher water uptake ability and better biocompatibility. The film was found to resist tearing under suture pullout strength in a hydrated state. In vitro cytotoxicity tests showed that the film was cytocompatible. A cell study using a human keratinocyte culture demonstrated enhanced cell adhesion, spreading, and proliferation on the BCAGG film compared with BC/alginate film. The BCAGG film therefore has significant potential for use in biomedical applications, particularly in dermal treatment, skin tissue regeneration, and wound healing.
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