成像体模
计算机科学
匹配(统计)
数据采集
人工智能
噪音(视频)
模式识别(心理学)
核医学
金标准(测试)
核磁共振
数学
物理
图像(数学)
医学
统计
操作系统
作者
Elisa Roccia,Rohini Vidya Shankar,Radhouène Neji,Gastão Cruz,Camila Muñoz,René M. Botnar,Vicky Goh,Claudia Prieto,Isabel Dregely
摘要
Purpose To develop a fast and accurate method for 3D T 2 mapping of prostate cancer using undersampled acquisition and dictionary‐based fitting. Methods 3D high‐resolution T 2 ‐weighted images (0.9 × 0.9 × 3 mm 3 ) were obtained with a multishot T 2 ‐prepared balanced steady‐state free precession (T 2 ‐prep‐bSSFP) acquisition sequence using a 3D variable density undersampled Cartesian trajectory. Each T 2 ‐weighted image was reconstructed using total variation regularized sensitivity encoding. A flexible simulation framework based on extended phase graphs generated a dictionary of magnetization signals, which was customized to the proposed sequence. The dictionary was matched to the acquired T 2 ‐weighted images to retrieve quantitative T 2 values, which were then compared to gold‐standard spin echo acquisition values using monoexponential fitting. The proposed approach was validated in simulations and a T 1 /T 2 phantom, and feasibility was tested in 8 healthy subjects. Results The simulation analysis showed that the proposed T 2 mapping approach is robust to noise and typically observed T 1 variations. T 2 values obtained in the phantom with T 2 prep‐bSSFP and the acquisition‐specific, dictionary‐based matching were highly correlated with the gold‐standard spin echo method (r = 0.99). Furthermore, no differences were observed with the accelerated acquisition compared to the fully sampled acquisition (r = 0.99). T 2 values obtained in prostate peripheral zone, central gland, and muscle in healthy subjects (age, 26 ± 6 years) were 97 ± 14, 76 ± 7, and 36 ± 3 ms, respectively. Conclusion 3D quantitative T 2 mapping of the whole prostate can be achieved in 3 minutes.
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