生物膜
胶束
百里香酚
壳聚糖
单核细胞增生李斯特菌
化学
抗菌剂
微生物学
金黄色葡萄球菌
精油
细菌
食品科学
生物
生物化学
水溶液
有机化学
遗传学
作者
Zhaojie Wang,Hu Bai,Chunbo Lu,Chunyan Hou,Yuanhao Qiu,Peng Zhang,Jinyou Duan,Haibo Mu
标识
DOI:10.1016/j.carbpol.2018.10.095
摘要
Bacterial biofilms are widely associated with persistent infections and food contamination. High resistance to conventional antimicrobial agents resulted in an urgent need for novel formulation to eliminate these bacterial communities. Herein we fabricated light controllable chitosan micelles loading with thymol (T-TCP) for elimination of biofilm. Due to the exterior chitosan, T-TCP micelles easily bind to negative biofilm through electrostatic interaction and efficiently deliver the essential oil payloads. Under irradiation, T-TCP micelles generated ROS, which triggered simultaneous thymol release and also resulted in additional ROS-inducing bactericidal effects, both effectively eradicating biofilms of Listeria monocytogenes and Staphylococcus aureus. This formulation provided a platform for other water-insoluble antimicrobials and might be used as a potent and controllable solution to biofilm fighting.
科研通智能强力驱动
Strongly Powered by AbleSci AI