尿
药代动力学
排泄
代谢物
粪便
吸收(声学)
内科学
口服
内分泌学
化学
药理学
医学
生物
声学
物理
古生物学
作者
Takayuki Kifuji,Shinsuke Inoue,Megumi Furukawa,Begonya Perez Madera,Takahiro Goto,Hiroshi Kumagai,Stuart Mair,Akihiko Kawaguchi
出处
期刊:Xenobiotica
[Informa]
日期:2018-12-21
卷期号:49 (9): 1033-1043
被引量:6
标识
DOI:10.1080/00498254.2018.1525508
摘要
The absorption, metabolism and excretion of MT-1303 were investigated in healthy male subjects after a single oral dose of 0.4 mg [14C]-MT-1303 (ClinicalTrials.gov NCT02293967).The MT-1303 concentration in the plasma reached a maximum at 12 h after administration. Thereafter, the concentration declined with a half-life of 451 h. At the final assessment on Day 57, 91.16% of the administered radioactivity was excreted, and the cumulative excretion in the urine and faeces was 35.32% and 55.84%, respectively.The most abundant metabolite in plasma was MT-1303-P, which accounted for 42.6% of the area under the plasma concentration–time curve (AUC) of the total radioactivity. The major component excreted in urine was Human Urine (HU)4 (3066434), accounting for 28.1% of radioactivity in the sample (4.05% of the dose), whereas MT-1303 was a major component in the faeces, accounting for 89.8% of radioactivity in the sample (25.49% of the dose) up to 240 h after administration.This study indicates that multiple metabolic pathways are involved in the elimination of MT-1303 from the human body and the excretion of MT-1303 and MT-1303-P via the kidney is low. Therefore, MT-1303 is unlikely to cause conspicuous drug interactions or alter pharmacokinetics in patients with renal impairment.Trial registration: ClinicalTrials.gov identifier: NCT02293967.
科研通智能强力驱动
Strongly Powered by AbleSci AI